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KMID : 0043319920150010014
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Archives of Pharmacal Research
1992 Volume.15 No. 1 p.14 ~ p.19
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Reactions with Halogenated Compound: Synthesis of Several New Pyrazolo[3,2-c] triazine and 2-Benzenesulfonyglyoxal arylhydrazone Derivaties
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Abdelhamind AO
Attaby FA/Khalifa FA/Ghabrial SS
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Abstract
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Diazotized primary artomatic amines 4 coupled with the ketosulfones 1-3 in ethanol in the presence of sodium acetate at 0oC to afford the corresponding hydrazones 5-7. Also diazotized 3-aminopyrazoles 14 coupled with 1-3 in ethanolic sodium acetate to give the pyrazolotriazines 18-20 in good yields. Compounds 5-7 and 18 can also be obtained from the reaction of hydrazidoyl halides 8-10 and 21 with sodium benzenesulfinate. The hydrazones 11-13 can easy be oxidized to the hydrazones 5-7, using hydrogen peroxide in acetic acid.
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